molecular chaperone system - Search
  1. Nature
    https://www.nature.com/articles/s41467-021-22369-9

    The landscape of molecular chaperones across human tissues

    • The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little at… See more

    Introduction

    Chaperones are highly conserved molecular machines that control cellular protein homeostasis (proteostasis). Across species, they promote de novo protein folding and … See more

    Nature
    Results

    Chaperones are ubiquitously and highly expressed across human tissues
    We … See more

    Nature
    Discussion

    Chaperones are basic components of all living organisms, and are thus commonly regarded as house-keeping genes1. But, are all folding environments similar to each other? In a … See more

    Nature
    Methods

    Curation of an integrated list of human chaperones
    We compiled a curated list of 195 known human chaperone, co-chaperone, and folding enz… See more

    Nature
    Code availability

    Data of chaperones analyzed in the study are available as Supplementary Data 1. Data of tissues analyzed in the study appear in Supplementary Data 2. Data of disease-as… See more

    Nature
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  2. Molecular chaperones are diverse families of multidomain proteins that have evolved to assist nascent proteins to reach their native fold, protect subunits from heat shock during the assembly of complexes, prevent protein aggregation or mediate targeted unfolding and disassembly.
    Author: Helen R. Saibil
    Publish Year: 2013

    Chaperone machines for protein folding, unfolding and ... - Nature

    www.nature.com/articles/nrm3658
    www.nature.com/articles/nrm3658
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  3. People also ask
    What are molecular chaperones?
    In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation.

    Chaperone (protein) - Wikipedia

    en.wikipedia.org
    What is the role of chaperones in protein synthesis?
    Across species, they promote de novo protein folding and protein maturation 1, protein translocation 2, protein-complexes assembly and disassembly 3, protein disaggregation and refolding 4, and protein degradation 5. In accordance with their fundamental roles, chaperones are abundant proteins.

    The landscape of molecular chaperones across human tissues reveals a

    nature.com
    How do molecular chaperones prevent protein aggregation and misfolding?
    Efficient folding of many newly synthesized proteins depends on assistance from molecular chaperones, which serve to prevent protein misfolding and aggregation in the crowded environment of the cell. Nascent chain–binding chaperones, including trigger factor, Hsp70, and prefoldin, stabilize elongating chains on ribosomes in a nonaggregated state.

    Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

    science.org
    What is a chaperone enzyme?
    For a growing number of proteins, chaperone function is combined with an additional activity, as is the case for certain protein disulfide isomerases and peptidyl-prolyl isomerases, enzymes that catalyze rate-limiting steps in the folding of some proteins ( 14 ).

    Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

    science.org
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  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369298

    Molecular chaperones and protein quality control: an introduction …

     
  5. Nature
    https://www.nature.com/articles/nrm3658

    Chaperone machines for protein folding, unfolding and …

    WEBSep 12, 2013 · Molecular chaperones have key roles in protein quality control and recovery from stress conditions. They assist folding and …

    • Publish Year: 2013
  6. Wikipedia
    https://en.wikipedia.org/wiki/Chaperone_(protein)

    Chaperone (protein) - Wikipedia

  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042005

    The landscape of molecular chaperones across human tissues …

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600384

    Molecular Chaperones: Molecular Assembly Line Brings …

  9. Nature
    https://www.nature.com/articles/nature10317

    Molecular chaperones in protein folding and proteostasis | Nature

  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/24490731

    Molecular chaperone GroEL/ES: unfolding and refolding processes

  11. Science | AAAS
    https://www.science.org/doi/10.1126/scien…

    Molecular Chaperones in the Cytosol: from Nascent …

    WEBCytosolic chaperones participate in de novo folding mainly through two distinct mechanisms. Chaperones, such as trigger factor and the Hsp70s, act by holding nascent and newly synthesized chains in a state …

  12. wiley.com
    https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.201900441

    Mechanisms of Chaperones as Active Assistant/Protector for …

  13. ACS Publications
    https://pubs.acs.org/doi/10.1021/acs.bioconjchem.0c00133

    Artificial Molecular Chaperone Systems for Proteins, Nucleic …

  14. Cell Press
    https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00377-5

    The Hsp90 molecular chaperone governs client proteins by …

  15. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771373

    The Nuclear and DNA-Associated Molecular Chaperone Network

  16. springer.com
    https://link.springer.com/chapter/10.1007/978-94-007-4667-1_2

    Chaperones: General Characteristics and Classifications

  17. Nature
    https://www.nature.com/articles/s41580-019-0133-3

    The Hsp70 chaperone network | Nature Reviews Molecular Cell …

  18. nih.gov
    https://pubmed.ncbi.nlm.nih.gov/20453930

    Mechanisms of the Hsp70 chaperone system - PubMed

  19. Nature
    https://www.nature.com/articles/s41467-022-32268-2

    Multifunctional synthetic nano-chaperone for peptide folding and ...

  20. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0167488904002368

    Cooperation of molecular chaperones with the …

  21. Cell Press
    https://www.cell.com/fulltext/S0092-8674(00)00165-3

    Structure of the Molecular Chaperone Prefoldin: Cell

  22. Springer
    https://link.springer.com/article/10.1007/s10735-023-10119-8

    The chaperone system in cancer therapies: Hsp90 | Journal of …

  23. Cell Press
    https://www.cell.com/fulltext/S0092-8674(00)80928-9

    The Hsp70 and Hsp60 Chaperone Machines: Cell - Cell Press

  24. ACS Publications
    https://pubs.acs.org/doi/10.1021/acs.jpcb.4c03363

    Asymmetric Dynamics Drive Catalytic Activation of the Hsp90 …

  25. Nature
    https://www.nature.com/articles/nrm.2017.20

    The HSP90 chaperone machinery | Nature Reviews Molecular …

  26. Pharmaceutical Technology
    https://www.pharmaceutical-technology.com/data...

    BAG Family Molecular Chaperone Regulator 3 drugs in …

  27. MDPI
    https://www.mdpi.com/2076-3425/14/9/881

    Comprehensive Analysis of Age- and Sex-Related Expression of …

  28. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940948

    A History of Molecular Chaperone Structures in the Protein Data …

  29. Springer
    https://link.springer.com/article/10.1007/s10722-024-02143-8

    Integrating physiological and molecular insights in cotton

  30. Nature
    https://www.nature.com/articles/s41467-024-51657-3

    Chaperone solvent-assisted assembly of polymers at the ... - Nature